Q) A 40 year old man presented with itching, hyperpigmentation, lichenification and scaling in the antecubital fossa, with history of similar exacerbations and remissions in the past. His father is a known asthmatic. The immunoregulatory abnormalities seen in this patient are all except?
a) Increased IgE synthesis
b) Decreased expression of CD 23
c) Impaired delayed type hypersensitivity reactions
d) Increased serum IgE
Ans: b) (Harrison’s 16th Ed., 288)
Clinical features of Atopic Dermatitis are:
· Pruritus and scratching
· Course marked by exacerbations and remissions
· Lesions typical of eczematous dermatitis
· Personal or family history of atopy
· Clinical course lasting longer than 6 weeks
Patients with AD may display a variety of immunoregulatory abnormalities:
· Increased IgE synthesis
· Increased serum IgE
· Increased specific IgE to foods, aeroallergens, bacteria and bacterial products
· Increased expression of CD 23 (low affinity IgE receptor) on monocytes and B-cells
· Impaired delayed type hypersensitivity reactions.
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